What causes von Willebrand disease (vWD) type 2M?

Updated: Dec 30, 2019
  • Author: Eleanor S Pollak, MD; Chief Editor: Srikanth Nagalla, MBBS, MS, FACP  more...
  • Print
Answer

vWD type IIM (for multimer) involves qualitative variants with decreased platelet-dependent function not resulting from absence of high–molecular weight multimers. Type IIM vWD can result from a variety of mutations and is heterogeneous. In a study of 14 patients with vWD type IIM, the consistent findings were significant prolongation in PFA-100 and greatly reduced or absentristocetin-induced platelet aggregation and vWF ristocetin cofactor. [4]


Did this answer your question?
Additional feedback? (Optional)
Thank you for your feedback!