What causes von Willebrand disease (vWD) type 2M?

Updated: Dec 30, 2019
  • Author: Eleanor S Pollak, MD; Chief Editor: Srikanth Nagalla, MBBS, MS, FACP  more...
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vWD type IIM (for multimer) involves qualitative variants with decreased platelet-dependent function not resulting from absence of high–molecular weight multimers. Type IIM vWD can result from a variety of mutations and is heterogeneous. In a study of 14 patients with vWD type IIM, the consistent findings were significant prolongation in PFA-100 and greatly reduced or absentristocetin-induced platelet aggregation and vWF ristocetin cofactor. [4]

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