What causes von Willebrand disease (vWD) type 1?

Updated: Dec 30, 2019
  • Author: Eleanor S Pollak, MD; Chief Editor: Srikanth Nagalla, MBBS, MS, FACP  more...
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Answer

vWD type I causes a mild to moderate quantitative deficiency of vWF (ie, about 20-50% of normal levels). In individuals with vWF levels < 0.3 IU/mL, type I is usually inherited in autosomal dominant fashion; in those with levels >0.3 IU/mL mutations show variable penetrance. [3]


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