What are the cytogenetic findings of atypical papilloma and ductal carcinoma in situ (DCIS)?

Updated: Jun 18, 2020
  • Author: Oudai Hassan, MD; Chief Editor: Chandandeep Nagi, MD  more...
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Recent reports have shown that papillomas involved by DCIS show loss of heterozygosity (LOH) at several loci on chromosomes 16p and 16q, indicating these are clonal neoplasms. [6, 7] Although LOH at several of these loci have been identified in both IDP and DCIS involving a papilloma, LOH at 16q23 appears to be specific for the latter. [7] This specific LOH seen in DCIS involving a papilloma may reflect a characteristic abnormality in the lesion. However, further study is needed to confirm this.

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