What are the immunohistochemical findings characteristic of atypical papilloma and ductal carcinoma in situ (DCIS)?

Updated: Jun 18, 2020
  • Author: Oudai Hassan, MD; Chief Editor: Chandandeep Nagi, MD  more...
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Answer

Answer

The IDP component demonstrates layers of myoepithelial cells (eg, express p63, smooth muscle actin, h-caldesmon, myosin heavy chain) and overlying epithelium (eg, express CK7, CK8/18), the same as benign IDP (see Large, Central Intraductal Papillomas and Small, Peripheral Intraductal Papillomas). Myoepithelial markers highlight myoepithelial cells surrounding the intraductal papilloma and lining the fibrovascular cores. The DCIS component stains like common DCIS and lacks myoepithelial marker expression.


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