Which lab studies are performed in the evaluation of delayed hemolytic transfusion reactions (DHTRs)?

Updated: Jan 02, 2019
  • Author: S Gerald Sandler, MD, FACP, FCAP; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

In delayed hemolytic transfusion reactions (DHTRs), accelerated hemolysis is indicated by increased serum bilirubin and lactate dehydrogenase concentrations and a decline in total hemoglobin compared with the early post-transfusion value. Mekontso Dessap et al reported that a sharp decline in the hemoglobin A concentration is characteristic of DHTRs, and proposed a diagnostic nomogram for DHTR based on hemoglobin A concentration as a biologic marker of the survival of transfused red blood cells. [57]


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