Which medications in the drug class Antiplatelet Agents are used in the treatment of Secondary Thrombocytosis?

Updated: Dec 24, 2018
  • Author: Koyamangalath Krishnan, MD, FRCP, FACP; Chief Editor: Srikanth Nagalla, MBBS, MS, FACP  more...
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Answer

Antiplatelet Agents

Antiplatelet agents inhibit platelet function by inhibition of the platelet cyclooxygenase system.

Aspirin (Anacin, Ascriptin, Bayer Aspirin)

Irreversibly acetylates (and inactivates) platelet and endothelial cell cyclooxygenase. A lower dose (65 mg) preferentially inhibits the platelet cyclooxygenase system (responsible for thromboxane A2 production) while preserving the beneficial effects of endothelial cell prostacyclin production due to difference in sensitivity to the inhibition by aspirin of cyclooxygenases at different sites and due to turnover of the endothelial cell cyclooxygenases.


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