What is the role of platelet transfusion in the treatment of thrombotic thrombocytopenic purpura (TTP)?

Updated: May 25, 2021
  • Author: Theodore Wun, MD, FACP; Chief Editor: Srikanth Nagalla, MD, MS, FACP  more...
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Platelet transfusions should be avoided unless life-threatening (usually central nervous system) bleeding is present. Anecdotal reports have documented myocardial infarction and stroke following platelet transfusion in patients with TTP. In a single-institution review, Zhou et al found that of 233 patients with TTP, 15 patients had received platelet transfusions, with variable responses; in general, platelet transfusion was not detrimental, but its efficacy was uncertain. [27]

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