What is the role of cryopoor plasma (or cryosupernatant) in the treatment of thrombotic thrombocytopenic purpura (TTP)?

Updated: Feb 18, 2019
  • Author: Theodore Wun, MD, FACP; Chief Editor: Srikanth Nagalla, MBBS, MS, FACP  more...
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Answer

In patients whose TTP is refractory to plasma exchange, using cryopoor plasma (or cryosupernatant) has sometimes led to a response. This is fresh frozen plasma that has had the cryoprecipitate removed and is thus depleted of high-molecular-weight von Willebrand multimers, which have a pathogenic role in TTP. However, a meta-analysis of three trials that compared plasma exchange using cryosupernatant plasma with plasma exchange using fresh frozen plasma showed no difference between the two. [20]


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