What are the signs and symptoms of thrombotic thrombocytopenic purpura (TTP)?

Updated: May 25, 2021
  • Author: Theodore Wun, MD, FACP; Chief Editor: Srikanth Nagalla, MD, MS, FACP  more...
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Patients with thrombotic thrombocytopenic purpura (TTP) typically report an acute or subacute onset of the following symptoms related to central nervous system (CNS) dysfunction, anemia, or thrombocytopenia:

  • Neurologic manifestations include alteration in mental status, seizures, hemiplegia, paresthesias, visual disturbance, and aphasia

  • Fatigue may accompany the anemia

  • Severe bleeding from thrombocytopenia is unusual, although petechiae are common

Clinical manifestations may also include the following:

  • Fever occurs in approximately 50% of patients

  • Patients may notice dark urine from hemoglobinuria.

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