Which patient groups have the highest prevalence of thrombotic thrombocytopenic purpura (TTP)?

Updated: Feb 18, 2019
  • Author: Theodore Wun, MD, FACP; Chief Editor: Srikanth Nagalla, MBBS, MS, FACP  more...
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Answer

An ethnic predisposition to TTP is not established. In the larger series reported, a female predominance of approximately 2:1 has been noted.

In several large studies, the median age at diagnosis is approximately 40 years. However, in the authors' series of 126 consecutive patients, the median age was 52 years.

In general, HUS is diagnosed in children and TTP is diagnosed in adults; 90% of cases of HUS occur in children. Bouw et al have presented a review article of TTP in children. [11]


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