What is the prevalence of thrombotic thrombocytopenic purpura (TTP)?

Updated: Feb 18, 2019
  • Author: Theodore Wun, MD, FACP; Chief Editor: Srikanth Nagalla, MBBS, MS, FACP  more...
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Answer

Exact incidence figures for the United States are not available, although TTP is thought to be a rare disease. In one series, the frequency was approximately 1 in 50,000 hospital admissions. Over a 25-year period in the Sacramento, California region (population at risk, 1.2 million), at least 176 documented cases of TTP were reported. In another 1-year study, 20 institutions reported 115 patients with TTP.

Analysis of a French national registry found that the rate of TTP in France was 13 cases per million population. [4]  The age-sex standardized incidence of TTP and HUS has been estimated at 2.2 cases per million population per year in the United Kingdom and 3.2 cases per million population per year in Saskatchewan, Canada. [9]


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