What are the differences between thrombotic thrombocytopenic purpura (TTP) and hemolytic-uremic syndrome (HUS)?

Updated: May 25, 2021
  • Author: Theodore Wun, MD, FACP; Chief Editor: Srikanth Nagalla, MD, MS, FACP  more...
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A closely related disorder, hemolytic-uremic syndrome (HUS), shares many clinical characteristics of TTP but is more common in children. Renal abnormalities tend to be more severe in HUS. Although the two disorders were once considered variants of a single syndrome, current evidence suggests differing pathogenic mechanisms of TTP and HUS. The routine use of aggressive high-volume total plasma exchange (TPE) greatly reduces the mortality of TTP, whereas the effect of TPE on the outcome of patients with HUS is more controversial.

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