How is refractory thrombotic thrombocytopenic purpura (TTP) treated?

Updated: Feb 18, 2019
  • Author: Theodore Wun, MD, FACP; Chief Editor: Srikanth Nagalla, MBBS, MS, FACP  more...
  • Print
Answer

In those patients refractory to plasma exchange, using cryopoor plasma (or cryosupernatant) has sometimes led to a response. This is fresh frozen plasma that has had the cryoprecipitate removed and is thus depleted of high-molecular-weight von Willebrand multimers, which have a pathogenic role in TTP.

Corticosteroids may also be used in refractory TTP. Rituximab, although not approved for use in TTP, is increasingly recommended for use in refractory cases.

See Treatment and Medication for more detail.


Did this answer your question?
Additional feedback? (Optional)
Thank you for your feedback!