What is the role of plasma exchange in the treatment of thrombotic thrombocytopenic purpura (TTP)?

Updated: Feb 18, 2019
  • Author: Theodore Wun, MD, FACP; Chief Editor: Srikanth Nagalla, MBBS, MS, FACP  more...
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Answer

The therapy of choice for TTP is plasma exchange with fresh frozen plasma. Because only 20-30% of patients present with the classic pentad, initiating total plasma exchange is justified by the presence of microangiopathic hemolytic anemia (schistocytes, elevated LDH, and indirect hyperbilirubinemia) and thrombocytopenia in the absence of other obvious causes (DIC, malignant hypertension).


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