How is thrombotic thrombocytopenic purpura (TTP) diagnosed?

Updated: Feb 18, 2019
  • Author: Theodore Wun, MD, FACP; Chief Editor: Srikanth Nagalla, MBBS, MS, FACP  more...
  • Print
Answer

Laboratory studies for suspected TTP include a CBC, platelet count, blood smears, coagulation studies, BUN creatinine, and serum bilirubin and lactate dehydrogenase.

The exact etiology of TTP is unknown. Most sporadic cases of TTP appear to be associated with severe deficiency of ADAMTS13 activity due to autoantibodies against this protease. [3, 4]  Measuring ADAMTS13 activity level may aid in diagnosis.

Imaging studies and biopsies are not required for diagnosis.

See Workup for more detail.


Did this answer your question?
Additional feedback? (Optional)
Thank you for your feedback!