What causes hyperglycemia in HIV infection?

Updated: Apr 09, 2019
  • Author: Jason F Okulicz, MD, FACP, FIDSA; Chief Editor: Michael Stuart Bronze, MD  more...
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Answer

Answer

Patients taking ARVs, especially certain PIs and NRTIs, have an increased risk of hyperglycemia and diabetes mellitus. The incidence of newly onset hyperglycemia among HIV-infected patients on ART has been reported as about 5%, on average. Diagnosis of diabetes mellitus equating to a HbA1C value of 6.5% is defined by the American Diabetes Association. [19] However, a lower HbA1C threshold of 5.8% has also been suggested, as this cutoff has been associated with better sensitivity and specificity for patients on ART. [20]


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