What causes lipoatrophy in HIV infection?

Updated: Apr 09, 2019
  • Author: Jason F Okulicz, MD, FACP, FIDSA; Chief Editor: Michael Stuart Bronze, MD  more...
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The comorbidities listed below may require management.

Abnormalities of body fat distribution

These are a recognized complication of ART. Lipohypertrophy has been variably associated with PIs and with nucleoside reverse transcriptase inhibitors (NRTIs). Lipoatrophy is most commonly associated with NRTIs, specifically stavudine, didanosine, and zidovudine. Once body shape changes occur, they cannot be reliably reversed, and switching to an NRTI-sparing regimen can slowly improve limb fat in patients with lipoatrophy but does not help patients with lipohypertrophy.

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