What causes rash in HIV infection?

Updated: Sep 07, 2018
  • Author: Jason F Okulicz, MD, FACP, FIDSA; Chief Editor: Michael Stuart Bronze, MD  more...
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Answer

Answer

Rash is probably the most common symptom. During routine workup, possible drug-induced rash should be excluded. The 2 main ARVs that cause rash are nevirapine and abacavir. Nevirapine can cause a mild rash; moderate to severe rash with or without hepatitis requires discontinuation. Rash due to abacavir may occur in isolation or as part of the abacavir hypersensitivity reaction. The risk of hypersensitivity is closely linked to HLA-B*5701. Therefore, before starting an abacavir-containing regimen, patients should be tested for HLA-B*5701.


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