According to the ASH guidelines, what are the indications for silent cerebral infarcts screening in patients with sickle cell disorder (SCD)?

Updated: May 12, 2021
  • Author: Joseph E Maakaron, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Screening for silent cerebral infarcts in children and adults with HbSS or HbSβ0 thalassemia:

  • At least a one-time magnetic resonance imaging (MRI) screening, without sedation, is recommended to detect silent cerebral infarcts in early school-aged children. This recommendation is made in view of the fact that silent cerebral infarcts are highly prevalent in children with HbSS or HbSβ0 thalassemia (1 in 3) and are associated with cognitive impairment, poor school performance, and future cerebral infarcts.

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