Which medications in the drug class Hemoglobin Oxygen-Affinity Modulators are used in the treatment of Sickle Cell Anemia?

Updated: May 12, 2021
  • Author: Joseph E Maakaron, MD; Chief Editor: Emmanuel C Besa, MD  more...
  • Print
Answer

Hemoglobin Oxygen-Affinity Modulators

Voxelotor is a hemoglobin S (HbS) polymerization inhibitor that binds to HbS with a 1:1 stoichiometry and exhibits preferential partitioning to RBCs. By increasing the affinity of Hb for oxygen, voxelotor demonstrates dose-dependent inhibition of HbS polymerization.

Voxelotor (Oxbryta)

Indicated for treatment of sickle cell disease in adults and adolescents aged 12 years or older.


Did this answer your question?
Additional feedback? (Optional)
Thank you for your feedback!