Which medications in the drug class P-Selectin Inhibitor are used in the treatment of Sickle Cell Disease (SCD)?

Updated: Oct 25, 2022
  • Author: Joseph E Maakaron, MD; Chief Editor: Emmanuel C Besa, MD  more...
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P-Selectin Inhibitor

Binding P-selectin on the surface of the activated endothelium and platelet cells blocks interactions between endothelial cells, platelets, red blood cells, and leukocytes; thereby, decreasing vaso-occlusive crises.

Crizanlizumab (Adakveo, crizanlizumab-tmca)

P-selectin inhibitor indicated to reduce frequency of vasoocclusive crises in adults with sickle cell disease.

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