What are the increased risks for patients with sickle cell disease (SCD) who have undergone a splenectomy?

Updated: May 12, 2021
  • Author: Joseph E Maakaron, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Patients who have undergone a splenectomy as part of their SCD treatment regimen have an increased risk of infection with encapsulated organisms, such as Streptococcus pneumoniae. [105] Pneumococcal and influenza vaccination is safe in patients with functioning kidney transplants. [106, 107, 108] However, the use of live vaccines is contraindicated due to the immunosuppressive therapy that these patients require.

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