How is recurrent priapism prevented in patients with sickle cell disease (SCD)?

Updated: May 12, 2021
  • Author: Joseph E Maakaron, MD; Chief Editor: Emmanuel C Besa, MD  more...
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New approaches to prevent recurrent priapism include use of phosphodiesterase type 5 inhibitors (eg, sildenafil, tadalafil). In a pilot study and a small randomized, controlled trial (n = 13), long-term treatment with these agents alleviated recurrent priapism in some patients with SCD. [92, 93] However, a systematic review of sidenafil, stilbestrol, etilefrine, or ephedrine to reduce the frequency of stuttering priapism in boys and men with SCD identified only three trials with 102 participants, and concluded that there is a lack of evidence for the benefits or risks of these drugs in this setting. [94]

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