How is megaloblastic anemia prevented in patients with sickle cell disease (SCD)?

Updated: May 12, 2021
  • Author: Joseph E Maakaron, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

Anemia is usually well tolerated. Because of the high RBC turnover, folate stores are often depleted. Althogh no scientific evidence shows that patients develop folate deficiency, folic acid (1 mg/d) is commonly prescribed for adults to prevent development of megaloblastic anemia due to increased folate requirements caused by hemolysis. Folic acid supplementation may raise the Hb level and support a healthy reticulocyte response.


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