What is the role of tricyclic antidepressants in the treatment of chronic pain in patients with sickle cell disease (SCD)?

Updated: May 12, 2021
  • Author: Joseph E Maakaron, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

The addition of tricyclic antidepressants may reduce the dose and need for opiates by interfering with pain perception. In addition, many patients with chronic pain are depressed, and lifting the depression has a salutary effect on the pain as it elevates the pain threshold


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