How is acute chest syndrome (ACS) treated in patients with sickle cell disease (SCD)?

Updated: May 12, 2021
  • Author: Joseph E Maakaron, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

Empiric antibiotics should be initiated and given intravenously, after obtaining samples for appropriate cultures. The antibiotics chosen should be active against Streptococcus pneumoniae, Mycoplasma pneumoniae, and Chlamydia; for the latter two, a macrolide may be appropriate. Antibiotic changes are based on response to therapy and results of cultures and sensitivities.


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