How can acute chest syndrome (ACS) complications in patients with sickle cell disease (SCD) be prevented?

Updated: May 12, 2021
  • Author: Joseph E Maakaron, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

Simple transfusion administered early may halt progressive respiratory deterioration, preventing complications such as increasing tachypnea and need for supplemental oxygen. If necessary, an exchange transfusion is performed by removing 1 unit of blood and transfusing 1 unit. The aim is to reduce the concentration of HbS to less than 30%. This can be achieved by repeating the exchange transfusion or by using a continuous-flow pheresis.

Adults, in general, need a higher rate of transfusions and longer hospitalization than children.


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