Which test provides an accurate measure of tissue iron concentration in patients with sickle cell disease (SCD)?

Updated: May 12, 2021
  • Author: Joseph E Maakaron, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

With continued transfusion, iron overload inevitably develops and can result in heart and liver failure, and multiple other complications. Serum ferritin is an inaccurate means of estimating the iron burden; liver iron evaluation, or perhaps MRI, is a more accurate means of determining tissue iron concentration and the response to chelation.


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