What are the indications for hydroxyurea in patients with sickle cell disease (SCD)?

Updated: May 12, 2021
  • Author: Joseph E Maakaron, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Hydroxyurea is usually prescribed by a hematologist, using rigorous selection criteria. Indications for hydroxyurea include the following:

  • Frequent painful episodes (six or more per year) [54]
  • History of acute chest syndrome
  • History of other severe vaso-occlusive events
  • Severe symptomatic anemia
  • Severe unremitting chronic pain that cannot be controlled with conservative measures
  • History of stroke or a high risk for stroke

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