Which tests should be performed in febrile children with sickle cell disease (SCD)?

Updated: May 12, 2021
  • Author: Joseph E Maakaron, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

Febrile children with SCD, especially those younger than 5 years, should have an aggressive investigation. The following are usually indicated:

  • CBC with differential and reticulocyte count

  • Liver function tests (LFTs)

  • Urinalysis

  • Blood cultures

Additional studies may be indicated, depending on the clinical presentation. Type and crossmatch blood in case transfusion is necessary.


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