Which hemoglobin screening results suggest sickle cell disease (SCD)?

Updated: May 12, 2021
  • Author: Joseph E Maakaron, MD; Chief Editor: Emmanuel C Besa, MD  more...
  • Print

Fetal hemoglobin is predominant in young infants. If results show only hemoglobin (Hb) F and S, the child has either sickle cell anemia or HbS–β-0 thalassemia. If results show HbF, S, and C, the child has HbSC disease. If results show HbF, S, and A, determine whether the child has received a transfusion.

If the child has not received a transfusion and S is greater than A, HbS–beta+ thalassemia is most likely the diagnosis. If A is greater than S, the child is presumed to have the sickle trait. If A and S concentrations are close, conduct a study of the parents to determine if one of them has the thalassemia trait. Repeat Hb electrophoresis on the child after several months.

Did this answer your question?
Additional feedback? (Optional)
Thank you for your feedback!