What is the prevalence of sickle cell disease (SCD) in the US?

Updated: May 12, 2021
  • Author: Joseph E Maakaron, MD; Chief Editor: Emmanuel C Besa, MD  more...
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The following statistics are available from the Centers for Disease Control and Prevention and the National Institutes of Health [16, 17] :

  • Sickle cell anemia is the most common inherited blood disorder in the United States
  • In the United States, approximately 100,000 people have SCD
  • SCD occurs in about 1 of every 16,300 Hispanic-American births
  • Approximately 1 in 13 black or African Americans has sickle cell trait

In the United States, SCD accounts for less than 1% of all new cases of end-stage renal disease (ESRD). [18] The following factors are known to portend a greater likelihood of progression to overt renal failure: hypertension, nephrotic-range proteinuria, hematuria, severe anemia, and a Central African Republic heritage. [19, 20, 21] In patients with SCD, 5-18% develop renal failure. [22] In one study cohort, the median age at the time of renal failure in patients with SCD was 23.1 years.

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