Which growth defects may occur in patients with sickle cell disease (SCD)?

Updated: May 12, 2021
  • Author: Joseph E Maakaron, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

Patients with sickle cell disease can have a variety of growth defects due to the abnormal maturation of bone. The following growth defects are often seen in sickle cell disease:

  • Bone shortening (premature epiphyseal fusion)
  • Epiphyseal deformity with cupped metaphysis
  • Peg-in-hole defect of distal femur
  • Decreased height of vertebrae (short stature and kyphoscoliosis)

Go to Skeletal Sickle Cell Anemia for complete information on this topic.

SCD can result in significant skeletal muscle remodeling and reduced muscle functional capacities, which contribute to exercise intolerance and poor quality of life. [13] In addition, changes in muscle and joints can result in altered posture and impaired balance control. [14]


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