Which skeletal manifestations of sickle cell disease (SCD) are caused by bone marrow hyperplasia?

Updated: May 12, 2021
  • Author: Joseph E Maakaron, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Deossification due to marrow hyperplasia can bring about the following changes in bone:

  • Decreased density of the skull
  • Decreased thickness of outer tble of skull due to widening of diploe
  • Hair on-end striations of the calvaria
  • Osteoporosis sometimes leading to biconcave vertebrae, coarsening of trabeculae in long and flat bones, and pathologic fractures

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