Which physiological changes in red blood cells (RBCs) suggest sickle cell disease (SCD)?

Updated: May 12, 2021
  • Author: Joseph E Maakaron, MD; Chief Editor: Emmanuel C Besa, MD  more...
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The physiological changes in RBCs result in a disease with the following cardinal signs:

  1. Hemolytic anemia
  2. Painful vaso-occlusive crisis
  3. Multiple organ damage from microinfarcts, including heart, skeleton, spleen, and central nervous system

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