Which medications are used to treat sickle cell disease (SCD)?

Updated: May 12, 2021
  • Author: Joseph E Maakaron, MD; Chief Editor: Emmanuel C Besa, MD  more...
  • Print
Answer

SCD may be treated with the following medications:

  • Antimetabolites: Hydroxyurea
  • Hemoglobin oxygen-affinity modulators (eg, voxelotor)
  • P-selectin inhibitors (eg, crizanlizumab)
  • Opioid analgesics (eg, oxycodone/aspirin, methadone, morphine sulfate, oxycodone/acetaminophen, fentanyl, nalbuphine, codeine, acetaminophen/codeine)
  • Nonsteroidal analgesics (eg, ketorolac, aspirin, acetaminophen, ibuprofen)
  • Tricyclic antidepressants (eg, amitriptyline)
  • Antibiotics (eg, cefuroxime, amoxicillin/clavulanate, penicillin VK, ceftriaxone, azithromycin, cefaclor)
  • Vaccines (eg, pneumococcal, meningococcal, influenza, and recommended scheduled childhood/adult vaccinations)
  • Endothelin-1 receptor antagonists (eg, bosentan)
  • Phosphodiesterase inhibitors (eg, sildenafil, tadalafil)
  • Vitamins (eg, folic acid)
  • L-glutamine
  • Antiemetics (eg, promethazine)

Did this answer your question?
Additional feedback? (Optional)
Thank you for your feedback!