Which lab tests are performed in with the workup of sickle cell disease (SCD)?

Updated: May 12, 2021
  • Author: Joseph E Maakaron, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Laboratory tests used in patients with SCD include the following:

  • Mandatory screening for HbS at birth in the United States; prenatal testing can be obtained via chorionic villus sampling
  • Hemoglobin electrophoresis
  • CBC count with differential and reticulocyte count
  • Serum electrolytes
  • Hemoglobin solubility testing
  • Peripheral blood smear
  • Pulmonary function tests (transcutaneous O 2 saturation)
  • Renal function (creatinine, BUN, urinalysis)
  • Hepatobiliary function tests, (ALT, fractionated bilirubin)
  • CSF examination: Consider LP in febrile children who appear toxic and in those with neurologic findings (eg, neck stiffness, positive Brudzinski/Kernig signs, focal deficits); consider CT scanning before performing lumbar puncture
  • Blood cultures
  • ABGs
  • Secretory phospholipase A2 (sPLA2)

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