Which high-risk cardiac conditions in children require endocarditis prophylaxis?

Updated: Jun 01, 2020
  • Author: Samah Alasrawi, MD; Chief Editor: Buck Christensen  more...
  • Print


Antibiotic prophylaxis is indicated for the following high-risk cardiac conditions:

  • Prosthetic cardiac valve
  • History of infective endocarditis
  • Congenital heart disease (CHD) (antibiotic prophylaxis is recommended only for the following forms of CHD [and no others]): (1) unrepaired cyanotic CHD, including palliative shunts and conduits; (2) completely repaired congenital heart defect with prosthetic material or device, whether placed by surgery or by catheter intervention, during the first 6 months after the procedure; and (3) repaired CHD with residual defects at the site or adjacent to the site of a prosthetic patch or prosthetic device (which inhibits endothelialization)
  • Cardiac transplant recipients with valve regurgitation due to a structurally abnormal valve [4]

Prophylaxis is reasonable because endothelialization of prosthetic material occurs within 6 months after the procedure. [4]

Did this answer your question?
Additional feedback? (Optional)
Thank you for your feedback!