Which medications in the drug class Thrombin Inhibitors are used in the treatment of Protein S Deficiency?

Updated: Jan 03, 2021
  • Author: Mohammad Muhsin Chisti, MD, FACP; Chief Editor: Perumal Thiagarajan, MD  more...
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Answer

Thrombin Inhibitors

Prevent thrombus development through direct, competitive inhibition of thrombin.

Dabigatran (Pradaxa)

Prevents thrombus development through direct, competitive inhibition of thrombin Plasma half- life is 12-14 hours and duration of action is 24 hours.

Dabigatran etexilate is a prodrug that is rapidly hydrolyzed to dabigatran (active form) in the liver by plasma and hepatic esterases. It undergoes hepatic glucuronidation to active acylglucuronide isomers. Routine monitoring is not required; however, the measurement of activated partial thromboplastin time (aPTT), ecarin clotting test (ECT) if available, or thrombin time may be useful to determine presence of dabigatran and level of coagulopathy. Also, reversal agent has


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