What is the role of direct thrombin inhibitors in the treatment of protein S deficiency?

Updated: Jan 03, 2021
  • Author: Mohammad Muhsin Chisti, MD, FACP; Chief Editor: Perumal Thiagarajan, MD  more...
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Answer

Dabigatran  is another option for treatment of hypercoagulable states. In a post hoc analysis of data from the RECOVER, RE-COVER II, and RE-MEDY trials, Goldhaber et al reported no significant differences in rates of symptomatic VTE/VTE-related deaths between dabigatran etexilate and warfarin in patients with or without thrombophilia. [40]

Specific reversal agents for non–vitamin K antagonist oral anticoagulants are lacking, but idarucizumab, an antibody fragment, is available for reversing the anticoagulant effects of dabigatran.


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