What is the role of direct factor Xa inhibitors in the treatment of protein S deficiency?

Updated: Jan 03, 2021
  • Author: Mohammad Muhsin Chisti, MD, FACP; Chief Editor: Perumal Thiagarajan, MD  more...
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Answer

These agents bind to factor Xa and prevent it from cleaving prothrombin to thrombin. These drugs are widely used in multiple hypercoagulable states, including protein S deficiency, with evidence of comparable efficacy versus VKAs. Currently the oral agents that are available are rivaroxaban, apixaban, and edoxaban. [37, 38, 39]


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