When is screening for protein S deficiency indicated?

Updated: Jan 03, 2021
  • Author: Mohammad Muhsin Chisti, MD, FACP; Chief Editor: Perumal Thiagarajan, MD  more...
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Answer

Given the rarity of inherited protein S deficiency, testing for this disorder should not be considered in unselected patients with venous thromboembolism (VTE). However, screening for inherited thrombophilia is appropriate in cases of the following [27, 13, 15] :

  • VTE without obvious cause in patients younger than 45 to 50 years
  • VTE in patients with a family history of thrombosis
  • Recurrent VTE
  • Thrombosis at an unusual location
  • VTE during pregnancy, use of oral contraceptives, or hormone replacement therapy

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