What is the global prevalence of protein S deficiency?

Updated: Jan 03, 2021
  • Author: Mohammad Muhsin Chisti, MD, FACP; Chief Editor: Perumal Thiagarajan, MD  more...
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Data for European studies indicate the same frequencies for protein S deficiency as in the United States. In contrast, the prevalence of protein S deficiency is particularly high in the Japanese population, with a frequency of approximately 12.7% in patients with VTE and approximately 0.48%-0.63% in the general population. [16] In a Japanese study that evaluated patients with VTE for congenital thrombophilia, Ikejiri et al diagnosed congenital protein S deficiency in eight of 130 patients (6.2%). [17]

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