What is the role of intravesical liposomes in the treatment of interstitial cystitis/bladder pain syndrome (IC/BPS)?

Updated: Dec 04, 2020
  • Author: Eric S Rovner, MD; Chief Editor: Edward David Kim, MD, FACS  more...
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Answer

Experimental therapies include treatment with intravesical liposomes, which are vesicles composed of concentric phospholipid bilayers. [87] These adsorb to cell surfaces and act as a delivery mechanisms for various chemicals. Animal models have shown decreased bladder sensitivity to potassium chloride, [88] and small human studies have shown promising results in reduction of frequency, nocturia, pain, urgency, and O'Leary-Sant scores. [89] While these results are initially promising, large, randomized trials are still lacking.

In animal models, direct transplantation of stem cells into the bladder has proved beneficial. In addition, animal experiments suggest that stem cells may provide an autologous cell source for bladder tissue regeneration, in patients requiring bladder augmentation. [90]


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