What is the role of cyclosporine in the treatment of interstitial cystitis/bladder pain syndrome (IC/BPS)?

Updated: Dec 04, 2020
  • Author: Eric S Rovner, MD; Chief Editor: Edward David Kim, MD, FACS  more...
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Answer

In a randomized, prospective, nonblinded study, cyclosporine (a calcineurin inhibitor) significantly reduced micturition frequency and demonstrated superior clinical response rates when compared with pentosan polysulfate sodium; however, treatment-related toxicity was higher in the cyclosporine arm. [69] Further, response rates in some studies were much lower after treatment with cyclosporine in patients without Hunner ulcers. [70] Cyclosporine is currently included in the American Urological Association (AUA) guidelines as a fifth-line treatment option. [3]


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