What is the role of amitriptyline in the treatment of interstitial cystitis/bladder pain syndrome (IC/BPS)?

Updated: Dec 04, 2020
  • Author: Eric S Rovner, MD; Chief Editor: Edward David Kim, MD, FACS  more...
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Answer

In a randomized, double-blind, placebo-controlled study, amitriptyline was shown to provide statistically significant improvement in the O'Leary-Sant interstitial cystitis symptom index and problem index, pain, and urgency intensity. Common adverse effects of amitriptyline include dry mouth, weight gain, constipation, and sedation. [67]

In a 2010 intention-to-treat study by Foster et al, 271 women were randomized to behavioral therapy alone or therapy with amitriptyline dose escalation. No difference was found between the amitriptyline and placebo groups overall. However, subgroup analysis showed a mild improvement in symptoms in women on 50 mg of amitriptyline as compared with placebo. [68]


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