What is the role of histaminergic and muscarinic neurotransmitter receptors in the pathophysiology of interstitial cystitis/bladder pain syndrome (IC/BPS)?

Updated: Dec 04, 2020
  • Author: Eric S Rovner, MD; Chief Editor: Edward David Kim, MD, FACS  more...
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Answer

Up-regulation of histaminergic [15] and muscarinic neurotransmitter receptors has been shown to be present in patients with IC/BPS, which may contribute to the pain, urgency, and frequency that occurs in IC/BPS. [16, 17] Additionally, up-regulation of neural afferent pathways has been shown in IC/BPS, [18] as well as a central hyperresponsiveness in association with other conditions, including fibromyalgia, irritable bowel syndrome, and depression/anxiety disorders. [19]


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