According to CDC guidelines, what are the indications for preexposure prophylaxis (PrEP) for HIV?

Updated: Oct 08, 2019
  • Author: Alejandro Delgado, MD; Chief Editor: Michael Stuart Bronze, MD  more...
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Guidance from the CDC includes consideration for emtricitabine/tenofovir for use as PrEP among the following high-risk groups:

  • MSM who engage in high-risk behaviors. [4]

  • Heterosexually active adults, including women who may become pregnant while taking PrEP and serodiscordant couples [5]

  • Persons who inject illicit drugs. [6]

The guidelines include the following recommendations:

  • Evaluate for inconsistent use of other effective risk-reduction measures (eg, condom use)

  • Ascertain that the risk for HIV acquisition is high (eg, frequent partner change or concurrent partners in a geographic setting with high HIV prevalence)

  • To reduce the risk of transmission of drug resistance, do not start PrEP in persons with signs or symptoms of acute viral infection unless HIV-uninfected status is confirmed by HIV RNA testing or a repeat antibody test is performed after the viral syndrome resolves

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