Which medications in the drug class Sources of Exogenous Protein C are used in the treatment of Protein C Deficiency?

Updated: Jan 04, 2019
  • Author: Shamudheen Rafiyath, MD; Chief Editor: Perumal Thiagarajan, MD  more...
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Sources of Exogenous Protein C

A source of exogenous protein C in the form of either fresh frozen plasma or the protein C concentrate Ceprotin is used in the management of NPF and may also be employed in the treatment of WISN.

Protein C concentrate (Ceprotin)

A decision to administer protein C concentrate should take into consideration the protein C activity concentration, the severity of symptomatology, the cost, and the clinical scenario.

Although the concentrate is intended for IV use, reports of effective management with SC protein C concentrate have been documented in several cases of homozygous deficiency.

Ceprotin is indicated for prevention and treatment of life-threatening venous thrombosis and purpura fulminans caused by severe congenital protein C deficiency. Off-label use in the treatment of warfarin-induced skin necrosis in patients with heterozygous protein C deficiency has also been reported.

Fresh frozen plasma

Contains plasma components of whole blood.

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