How is protein C deficiency treated?

Updated: Jan 04, 2019
  • Author: Shamudheen Rafiyath, MD; Chief Editor: Perumal Thiagarajan, MD  more...
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A substantial proportion of individuals with protein C deficiency remain asymptomatic throughout life and require no specific therapy. However, thromboprophylaxis may be considered for such individuals, particularly if they have a strong family history of thrombosis, in situations associated with a high thrombotic risk, such as pregnancy and the postpartum state, surgery, and trauma.

A case report by Milleret and colleagues describes 2 years of successful prophylaxis in a patient with neonatal severe protein C deficiency, using warfarin oral suspension. The international normalized ratio (INR) was measured by home monitoring, with a target INR of 2.5 to 3.5. [69]

For those patients who do develop clinical manifestations of hereditary protein C deficiency, treatment depends on the particular clinical syndrome: venous thromboembolism (VTE), warfarin-induced skin necrosis (WISN), or neonatal purpura fulminans (NPF).

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